Article

Combinatorial action of regulatory systems generates colistin heteroresistance

2025-08-12

Abstract excerpt

<h4>ABSTRACT</h4> Heteroresistance is a form of antibiotic resistance in which a minor subpopulation of resistant cells coexists with a majority susceptible population. Colistin heteroresistance is common among Enterobacter cloacae clinical isolates, threatens its utility as a last-line therapeutic, and has become a model with which to understand the fundamental bases of heteroresistance. Despite numerous insigh...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 728bf3c9-af4b-5de0-9fa3-97b4c3890ee6
DOI: 10.1101/2025.08.11.668767

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Combinatorial action of regulatory systems generates colistin heteroresistanceDOI 10.1101/2025.08.11.668767Read

Bacterial heteroresistance mechanisms, dynamics, and emerging diagnostic approaches.Semantic proximity Read

Heterogeneity in microbial antibiotic responses: genetic basis and within-host evolution.Semantic proximity Read

Heteroresistance in <i>Enterococcus faecalis</i> is prevalent for key antibiotics and mainly caused by mutationsSemantic proximity Read

Colistin heteroresistance in Enterobacter due to base heterozygosity at certain phoP and phoQ locations.Semantic proximity Read

Heteroresistance to colistin in wild-type Klebsiella pneumoniae isolates from clinical originSemantic proximity Read

Heterogeneous resistance to colistin in Enterobacter cloacae complex due to a new small transmembrane proteinSemantic proximity Read

Study of the mechanisms of colistin heteroresistance in a strain of Enterobacter cloacae by random mutagenesis.Semantic proximity Read

Cryptic Evolution of Heteroresistance as Adaptation to Treatment InterruptionsSemantic proximity Read

Unstable tandem gene amplification generates heteroresistance (variation in resistance within a population) to colistin in Salmonella enterica.Semantic proximity Read

Colistin Heteroresistance in Klebsiella Pneumoniae Isolates and Diverse Mutations of PmrAB and PhoPQ in Resistant SubpopulationsSemantic proximity Read

Aminoglycoside heteroresistance in <i>Enterobacter cloacae</i> is driven by the cell envelope stress responseSemantic proximity Read

Antibiotic heteroresistance generated by multi-copy plasmidsSemantic proximity Read