Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adaptive resistance in bacteria requires epigenetic inheritance, genetic noise, and cost of efflux pumps.

PloS one - 1 Jan 2015

Motta Santiago Sandoval, Cluzel Philippe, Aldana Maximino

Abstract excerpt

Adaptive resistance emerges when populations of bacteria are subjected to gradual increases of antibiotics. It is characterized by a rapid emergence of resistance and fast reversibility to the non-resistant phenotype when the antibiotic is removed from the medium. Recent work shows that adaptive resistance requires epigenetic inheritance and heterogeneity of gene expression patterns that are, in particular,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Physiological
Share to Anti-Bacterial Agents
Share to Bacteria

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Gene Regulatory Networks

Share to Genes, Bacterial

Share to Inheritance Patterns

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 25781931
DOI: 10.1371/journal.pone.0118464
PMCID: PMC4363326

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adaptive resistance in bacteria requires epigenetic inheritance, genetic noise, and cost of efflux pumps.PMID 25781931Read ↗

Adaptive resistance to antibiotics in bacteria: a systems biology perspectiveSemantic proximity Read ↗

Interpreting phenotypic antibiotic tolerance and persister cells as evolution via epigenetic inheritance.Semantic proximity Read ↗

Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.Semantic proximity Read ↗

The Role of Efflux Pumps in the Transition from Low-Level to Clinical Antibiotic ResistanceSemantic proximity Read ↗

Forecasting multi-trait resistance evolution under antibiotic stressSemantic proximity Read ↗

Forecasting Multitrait Resistance Evolution under Antibiotic Stress.Semantic proximity Read ↗

Efflux-linked Accelerated Evolution of Antibiotic Resistance at a Population EdgeSemantic proximity Read ↗

Phenotypic heterogeneity in bacteria: the rise of antibiotic persistence, clinical implications, and therapeutic opportunities.Semantic proximity Read ↗

The Genomic Basis of Rapid Adaptation to Antibiotic Combination Therapy in Pseudomonas aeruginosaSemantic proximity Read ↗

Bacterial Persistence Modulates the Speed, Magnitude, and Onset of Antibiotic Resistance Evolution.Semantic proximity Read ↗

Stochasticity of gene expression as a motor of epigenetics in bacteria: from individual to collective behaviors.Semantic proximity Read ↗

Intrinsic Antimicrobial Resistance Determinants in the Superbug Pseudomonas aeruginosa.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.