Article

Single-cell transcriptomic dynamics exposes hidden survival trajectory under antibiotic treatment

2025-12-03

Abstract excerpt

Heterogeneity plays a major role in bacterial resistance to antibiotic treatment while the mechanism at single-cell level is largely unknown. Here, we employed a robust integration of bulk and bacterial single-cell RNA-seq (scRNA-seq) to uncover how individual cells of Acinetobacter baumannii reorganise the heterogenous transcriptome in response to antibiotic. Using polymyxin as a representative, bulk RNA-seq sho...

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Literature Corpus work: e60f90b5-c69b-5c91-a062-75104c81a690
DOI: 10.64898/2025.12.03.692042

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