Article
Acceleration of emergence of bacterial antibiotic resistance in connected microenvironments.
Science (New York, N.Y.) - 23 Sept 2011
Zhang Qiucen, Lambert Guillaume, Liao David, Kim Hyunsung, Robin Kristelle, Tung Chih-kuan, Pourmand Nader, Austin Robert H
Abstract excerpt
The emergence of bacterial antibiotic resistance is a growing problem, yet the variables that influence the rate of emergence of resistance are not well understood. In a microfluidic device designed to mimic naturally occurring bacterial niches, resistance of Escherichia coli to the antibiotic ciprofloxacin developed within 10 hours. Resistance emerged with as few as 100 bacteria in the initial inoculation....
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