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Article

EnvZ/OmpR-driven cooperative behavior promotes cefiderocol resistance in a hanging-droplet evolution system.

Science advances - 27 Mar 2026

Li Bowen, Song Kaiwen, Wang Qi, Gao Xu, Wang Ruobing, Shen Shitao, Wang Wei, Wang Hui

Abstract excerpt

Understanding how bacteria rapidly adapt to recently introduced antibiotics increasingly demands experimental models that move beyond classical evolution systems. We developed a microbial evolution hanging-droplet system (MEHS) that uses gravity-driven flow to sustain continuous exponential growth, doubling daily reproduction rate. Using this MEHS, Klebsiella pneumoniae rapidly adapted to fluctuating cefiderocol...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41894506
DOI: 10.1126/sciadv.aea4527
PMCID: PMC13025041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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