Article

Pancreatic Brsk2 amplifies parasympathetic signals to promote type 2 diabetes

2021-08-06

Abstract excerpt

<h4>ABSTRACT</h4> The parasympathetic nervous system (PNS) modulates postprandial glucose metabolism via innervating pancreas; however, its significance in the pathogenesis of type 2 diabetes (T2DM) remains unclear. Here we show that brain-specific serine/threonine-protein kinase 2 (Brsk2), accumulated in obese mouse islets, responds to PNS activation and initiates pre-absorptive insulin release. In inducible mou...

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Identifiers and source

Literature Corpus work: 00208bde-84c6-5c78-9d04-df354cf333e9
DOI: 10.1101/2021.08.05.455219

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