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Article

Cholinergic augmentation of insulin release requires ankyrin-B.

Science signaling - 16 Mar 2010

Healy Jane A, Nilsson Kent R, Hohmeier Hans E, Berglund Jelena, Davis Jonathan, Hoffman Janis, Kohler Martin, Li Luo-Sheng, Berggren Per-Olof, Newgard Christopher B, Bennett Vann

Abstract excerpt

Parasympathetic stimulation of pancreatic islets augments glucose-stimulated insulin secretion by inducing inositol trisphosphate receptor (IP(3)R)-mediated calcium ion (Ca2+) release. Ankyrin-B binds to the IP(3)R and is enriched in pancreatic beta cells. We found that ankyrin-B-deficient islets displayed impaired potentiation of insulin secretion by the muscarinic agonist carbachol, blunted carbachol-mediated...

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Identifiers

PMID: 20234002
DOI: 10.1126/scisignal.2000771

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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