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Minireview: Intraislet Regulation of Insulin Secretion in Humans

16 Nov 2013

Abstract excerpt

The higher organization of β-cells into spheroid structures termed islets of Langerhans is critical for the proper regulation of insulin secretion. Thus, rodent β-cells form a functional syncytium that integrates and propagates information encoded by secretagogues, producing a "gain-of-function" in hormone release through the generation of coordinated cell-cell activity. By contrast, human islets possess...

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PMID: 24243488
DOI: 10.1210/me.2013-1278

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