Article

Post-Inhibitory Rebound by δ-Cells Converts Inhibition into Excitation and Confers Islet Plasticity

2025-11-12

Abstract excerpt

The coordination of hormone secretion within the pancreatic islet remains incompletely understood. Here we identify post-inhibitory rebound (PIR), a transient excitatory overshoot of glucoregulatory hormones following inhibitory signaling, as a fundamental and previously unrecognized feature of islet physiology. Human islets from donors with type 2 diabetes displayed concomitantly elevated insulin and somatostatin...

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Literature Corpus work: 2eb08af7-9a33-51e0-aa0a-a4750f633b35
DOI: 10.1101/2025.11.10.687745

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