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Nonobese, insulin-deficient Ins2<sup>Akita</sup>mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling

3 Oct 2007

Abstract excerpt

Although insulin resistance has been traditionally associated with type 2 diabetes, recent evidence in humans and animal models indicates that insulin resistance may also develop in type 1 diabetes. A point mutation of insulin 2 gene in Ins2(Akita) mice leads to pancreatic beta-cell apoptosis and hyperglycemia, and these mice are commonly used to investigate type 1 diabetes and complications. Since insulin...

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PMID: 17911348
DOI: 10.1152/ajpendo.00256.2007

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