Article

Serine palmitoyltransferase-mediated de novo sphingolipid biosynthesis is required for normal insulin production and glucose tolerance

2025-05-17

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Aims/Hypothesis</h4> The importance for normal insulin secretion of ceramide synthesis is unclear. De novo ceramide synthesis requires serine palmitoyl transferase, SPT2, encoded by Sptl2 . <h4>Methods</h4> We generated β-cell-selective Sptl2 null mice by crossing animals with floxed alleles to mice expressing Cre recombinase from the Ins1 locus. Metabolic phenotyping, transcriptomi...

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Literature Corpus work: 96cdec1c-ad66-5a24-9667-3d74efe90ee9
DOI: 10.1101/2025.05.14.653935

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