Article
Constitutive Pleiotrophin Deletion Results in a Phenotype with an Altered Pancreatic Morphology and Function in Old Mice.
International journal of molecular sciences - 11 Oct 2024
Ballesteros-Pla Cristina, Sevillano Julio, Sánchez-Alonso María Gracia, Limones María, Pita Jimena, Zapatería Begoña, Sanz-Cuadrado Marta Inmaculada, Pizarro-Delgado Javier, Izquierdo-Lahuerta Adriana, Medina-Gómez Gema, Herradón Gonzalo, Ramos-Álvarez María Del Pilar
Abstract excerpt
Pleiotrophin (PTN) is crucial for embryonic development and pancreas organogenesis as it regulates metainflammation, metabolic homeostasis, thermogenesis, and glucose tolerance. Pleiotrophin deletion is associated with a lipodystrophic phenotype in which adipose tissue plasticity is altered in late life. This study explored the impact of pleiotrophin deletion on pancreatic morphology and function in later life....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.