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Chromosome Translocation, B Cell Lymphoma, and Activation-Induced Cytidine Deaminase

15 Sept 2012

Abstract excerpt

Studies of B cell lymphomas in the early 1980s led to the cloning of genes (c-MYC and IGH) at a chromosome translocation breakpoint. A rush followed to identify recurrently translocated genes in all types of cancer, which led to remarkable advances in our understanding of cancer genetics. B lymphocyte tumors commonly bear chromosome translocations to immunoglobulin genes, which points to a role for antibody gene...

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PMID: 22974238
DOI: 10.1146/annurev-pathol-020712-164004

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