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Epigenetic Function of Activation-Induced Cytidine Deaminase and Its Link to Lymphomagenesis

18 Dec 2014

Abstract excerpt

Activation-induced cytidine deaminase (AID) is essential for somatic hypermutation and class switch recombination of immunoglobulin (Ig) genes during B cell maturation and immune response. Expression of AID is tightly regulated due to its mutagenic and recombinogenic potential, which is known to target not only Ig genes, but also non-Ig genes, contributing to lymphomagenesis. In recent years, a new epigenetic...

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PMID: 25566255
DOI: 10.3389/fimmu.2014.00642

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