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Article

The IgH 3′ regulatory region and its implication in lymphomagenesis

15 Nov 2010

Abstract excerpt

The 3' regulatory region (3'RR) located downstream of the IgH gene is the master element that controls class switch recombination and sustains high-level transcription at the plasma-cell stage. This latter role suggests that the 3'RR may be involved in oncogene deregulation during the frequent IgH translocation events associated with B-cell malignancies. A convincing demonstration of the essential contribution of...

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PMID: 21080376
DOI: 10.1002/eji.201040778

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The IgH 3′ regulatory region and its implication in lymphomagenesisPMID 21080376Read ↗

Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region.Semantic proximity Read ↗

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A class switch control region at the 3' end of the immunoglobulin heavy chain locus.Semantic proximity Read ↗

Elucidation of IgH 3′ region regulatory role during class switch recombination via germline deletionSemantic proximity Read ↗

Human antibody heavy chain variable region exon interacts with 3’ regulatory region to form a stable somatic hypermutation centerSemantic proximity Read ↗

Identification of a homolog of the C alpha 3'/hs3 enhancer and of an allelic variant of the 3'IgH/hs1,2 enhancer downstream of the human immunoglobulin alpha 1 gene.Semantic proximity Read ↗

Activated mature B cells undergo enforced Sµ-3'RRrec in the λ-c-MYC mouse modelSemantic proximity Read ↗

Physiological role of the 3′IgH CBEs super-anchor in antibody class switchingSemantic proximity Read ↗

Homologous elements hs3a and hs3b in the 3' regulatory region of the murine immunoglobulin heavy chain (Igh) locus are both dispensable for class-switch recombination.Semantic proximity Read ↗

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Contribution of the IGCR1 regulatory element and the 3 <i>’Igh</i> CBEs to Regulation of <i>Igh</i> V(D)J RecombinationSemantic proximity Read ↗

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