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Article

B-cell tumorigenesis in mice carrying a yeast artificial chromosome-based immunoglobulin heavy/c-myc translocus is independent of the heavy chain intron enhancer (Emu).

Cancer research - 1 Nov 1999

Palomo C, Zou X, Nicholson I C, Bützler C, Brüggemann M

Abstract excerpt

We have used YAC (yeast artificial chromosome) technology to create large translocation regions where the c-myc proto-oncogene is coupled to the core region of the human immunoglobulin heavy chain (IgH) locus (from VH2-5 through to Cdelta). Chimeric mice were obtained from embryonic stem cells carrying a single copy of the 240-kb IgH/c-myc translocation region. B-cell tumorigenesis occurs in the translocus mice,...

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Topics

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Share to Chromosomes, Artificial, Yeast
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Heavy Chains

Share to Lymphoma, B-Cell

Share to Proto-Oncogene Mas

Share to Proto-Oncogene Proteins c-myc

Share to Tissue Distribution

Share to Transplantation Chimera

Source

Identifiers

PMID: 10554044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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