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Article

The 3' IgH locus control region is sufficient to deregulate a c-myc transgene and promote mature B cell malignancies with a predominant Burkitt-like phenotype.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2007

Truffinet Véronique, Pinaud Eric, Cogné Nadine, Petit Barbara, Guglielmi Laurence, Cogné Michel, Denizot Yves

Abstract excerpt

Burkitt lymphoma (BL) features translocations linking c-myc to an Ig locus. Breakpoints in the H chain locus (IgH) stand either close to J(H) or within switch regions and always link c-myc to the 3' IgH locus control region (3' LCR). To test the hypothesis that the 3' LCR alone was sufficient to deregulate c-myc, we generated mice carrying a 3' LCR-driven c-myc transgene and specifically up-regulating c-myc in B...

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Identifiers

PMID: 17947677
DOI: 10.4049/jimmunol.179.9.6033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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