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Restricting activation‐induced cytidine deaminase tumorigenic activity in B lymphocytes

24 Dec 2008

Abstract excerpt

DNA breaks play an essential role in germinal centre B cells as intermediates to immunoglobulin class switching, a recombination process initiated by activation-induced cytidine deaminase (AID). Immunoglobulin gene hypermutation is likewise catalysed by AID but is believed to occur via single-strand DNA breaks. When improperly repaired, AID-mediated lesions can promote chromosomal translocations (CTs) that...

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PMID: 19302140
DOI: 10.1111/j.1365-2567.2008.03050.x

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