Article

Sµ-3’RRrecHigh Chronic Lymphocytic Leukemia is associated with specific gene expression signature, activation-induced cMYC expression and sustained cell cycle entry.

2024-08-19

Abstract excerpt

<title>Abstract</title><p>Chronic lymphocytic leukemia (CLL) is an indolent non-Hodgkin B-cell lymphoma and is still incurable. In a previous study of CLL patients, the IGH locus DNA recombination between the switch µ (Sµ) and one 3’ regulatory regions (3’RR), the Sµ-3’RRrec, was detected more frequently than in normal condition. As a reminder, the Sµ-3'RRrec has been repeatedly detected in B-cells of mice and hum...

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Literature Corpus work: 6ac91e2b-2446-5f20-af1b-20cb2f4908fb
DOI: 10.21203/rs.3.rs-4923370/v1

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