Article

Negative linkage disequilibrium between amino acid changing variants reveals interference among deleterious mutations in the human genome

2020-01-15

Abstract excerpt

While there has been extensive work on patterns of linkage disequilibrium (LD) for neutral loci, the extent to which negative selection impacts LD is less clear. Forces like Hill-Robertson interference and negative epistasis are expected to lead to deleterious mutations being found on distinct haplotypes. However, the extent to which these forces depend on the selection and dominance coefficients of deleterious mu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0014b862-9344-5d75-8e02-593c9280f6a8
DOI: 10.1101/2020.01.15.907097

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Negative linkage disequilibrium between amino acid changing variants reveals interference among deleterious mutations in the human genomeDOI 10.1101/2020.01.15.907097Read

Negative linkage disequilibrium between amino acid changing variants reveals interference among deleterious mutations in the human genome.Semantic proximity Read

Local fitness and epistatic effects lead to distinct patterns of linkage disequilibrium in protein-coding genesSemantic proximity Read

Evidence for hitchhiking of deleterious mutations within the human genome.Semantic proximity Read

Natural selection affects multiple aspects of genetic variation at putatively neutral sites across the human genome.Semantic proximity Read

Negative selection in humans and fruit flies involves synergistic epistasis.Semantic proximity Read

Assessing the evolutionary impact of amino acid mutations in the human genome.Semantic proximity Read

Decreased adaptation at human disease genes as a possible consequence of interference between advantageous and deleterious variantsSemantic proximity Read

Positive and negative selection on the human genome.Semantic proximity Read

Analyses of allele age and fitness impact reveal human beneficial alleles to be older than neutral controlsSemantic proximity Read

Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing SelectionSemantic proximity Read

Negative selection in humans and fruit flies involves synergistic epistasisSemantic proximity Read

Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing Selection.Semantic proximity Read