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Article

Negative linkage disequilibrium between amino acid changing variants reveals interference among deleterious mutations in the human genome.

PLoS genetics - 1 Jul 2021

Garcia Jesse A, Lohmueller Kirk E

Abstract excerpt

Evolutionary forces like Hill-Robertson interference and negative epistasis can lead to deleterious mutations being found on distinct haplotypes. However, the extent to which these forces depend on the selection and dominance coefficients of deleterious mutations and shape genome-wide patterns of linkage disequilibrium (LD) in natural populations with complex demographic histories has not been tested. In this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34319975
DOI: 10.1371/journal.pgen.1009676
PMCID: PMC8351996

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