Article
Positive and negative selection on the human genome.
Genetics - 1 Jul 2001
Fay J C, Wyckoff G J, Wu C I
Abstract excerpt
The distinction between deleterious, neutral, and adaptive mutations is a fundamental problem in the study of molecular evolution. Two significant quantities are the fraction of DNA variation in natural populations that is deleterious and destined to be eliminated and the fraction of fixed differences between species driven by positive Darwinian selection. We estimate these quantities using the large number of...
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