Article
Natural selection affects multiple aspects of genetic variation at putatively neutral sites across the human genome.
PLoS genetics - 1 Oct 2011
Lohmueller Kirk E, Albrechtsen Anders, Li Yingrui, Kim Su Yeon, Korneliussen Thorfinn, Vinckenbosch Nicolas, Tian Geng, Huerta-Sanchez Emilia, Feder Alison F, Grarup Niels, Jørgensen Torben, Jiang Tao, Witte Daniel R, Sandbæk Annelli, Hellmann Ines, Lauritzen Torsten, Hansen Torben, Pedersen Oluf, Wang Jun, Nielsen Rasmus
Abstract excerpt
A major question in evolutionary biology is how natural selection has shaped patterns of genetic variation across the human genome. Previous work has documented a reduction in genetic diversity in regions of the genome with low recombination rates. However, it is unclear whether other summaries of genetic variation, like allele frequencies, are also correlated with recombination rate and whether these...
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