Article

Decreased adaptation at human disease genes as a possible consequence of interference between advantageous and deleterious variants

2021-03-31

Abstract excerpt

Advances in genome sequencing have dramatically improved our understanding of the genetic basis of human diseases, and thousands of human genes have been associated with different diseases. Despite our expanding knowledge of gene-disease associations, and despite the medical importance of disease genes, their evolution has not been thoroughly studied across diverse human populations. In particular, recent genomic...

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Literature Corpus work: 333ab759-70ef-581c-b6dc-0ec7bc456b2b
DOI: 10.1101/2021.03.31.437959

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