Article

Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing Selection

2016-05-16

Abstract excerpt

Deleterious mutations are expected to evolve under negative selection and are usually purged from the population. However, deleterious alleles segregate in the human population and some disease-associated variants are maintained at considerable frequencies. Here we test the hypothesis that balancing selection may counteract purifying selection in neighboring regions and thus maintain deleterious variants at higher...

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Literature Corpus work: 70294b9c-aaa0-56e1-82c2-c22f72462eec
DOI: 10.1101/053793

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