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Article

Evidence for hitchhiking of deleterious mutations within the human genome.

PLoS genetics - 1 Aug 2011

Chun Sung, Fay Justin C

Abstract excerpt

Deleterious mutations present a significant obstacle to adaptive evolution. Deleterious mutations can inhibit the spread of linked adaptive mutations through a population; conversely, adaptive substitutions can increase the frequency of linked deleterious mutations and even result in their fixation. To assess the impact of adaptive mutations on linked deleterious mutations, we examined the distribution of...

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Identifiers

PMID: 21901107
DOI: 10.1371/journal.pgen.1002240
PMCID: PMC3161959

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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