Article

Local fitness and epistatic effects lead to distinct patterns of linkage disequilibrium in protein-coding genes

2021-03-25

Abstract excerpt

Selected mutations interfere and interact with evolutionary processes at nearby loci, distorting allele frequency trajectories and creating correlations between pairs of mutations. A number of recent studies have used patterns of linkage disequilibrium (LD) between selected variants to test for selective interference and epistatic interactions, with some disagreement over interpreting observations from data. Inter...

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Literature Corpus work: b78276a5-e9c7-5a3a-8adb-9e797da249f0
DOI: 10.1101/2021.03.25.437004

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