Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing Selection.

doi:10.1093/molbev/msw127

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Article

Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing Selection.

Molecular biology and evolution - 1 Oct 2016

Lenz Tobias L, Spirin Victor, Jordan Daniel M, Sunyaev Shamil R

Abstract excerpt

Deleterious mutations are expected to evolve under negative selection and are usually purged from the population. However, deleterious alleles segregate in the human population and some disease-associated variants are maintained at considerable frequencies. Here, we test the hypothesis that balancing selection may counteract purifying selection in neighboring regions and thus maintain deleterious variants at...

Topics

Alleles
Biological Evolution
Computer Simulation
Databases, Genetic
Evolution, Molecular
Gene Frequency
Genetic Variation
Genome, Human
HLA Antigens
Haplotypes
Humans
Major Histocompatibility Complex
Polymorphism, Genetic
Selection, Genetic
Sequence Deletion

Source

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Identifiers

PMID: 27436009
DOI: 10.1093/molbev/msw127
PMCID: PMC5026253

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