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Article

Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing Selection.

Molecular biology and evolution - 1 Oct 2016

Lenz Tobias L, Spirin Victor, Jordan Daniel M, Sunyaev Shamil R

Abstract excerpt

Deleterious mutations are expected to evolve under negative selection and are usually purged from the population. However, deleterious alleles segregate in the human population and some disease-associated variants are maintained at considerable frequencies. Here, we test the hypothesis that balancing selection may counteract purifying selection in neighboring regions and thus maintain deleterious variants at...

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Identifiers

PMID: 27436009
DOI: 10.1093/molbev/msw127
PMCID: PMC5026253

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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