Article

Negative selection in humans and fruit flies involves synergistic epistasis

2016-07-29

Abstract excerpt

Negative selection against deleterious alleles produced by mutation is the most common form of natural selection, which strongly influences within-population variation and interspecific divergence. However, some fundamental properties of negative selection remain obscure. In particular, it is still not known whether deleterious alleles affect fitness independently, so that cumulative fitness loss depends exponenti...

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Literature Corpus work: cad81dc7-0842-5404-843d-dfb4c4f64a1f
DOI: 10.1101/066407

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