Article
Negative selection in humans and fruit flies involves synergistic epistasis.
Science (New York, N.Y.) - 5 May 2017
Sohail Mashaal, Vakhrusheva Olga A, Sul Jae Hoon, Pulit Sara L, Francioli Laurent C, van den Berg Leonard H, Veldink Jan H, de Bakker Paul I W, Bazykin Georgii A, Kondrashov Alexey S, Sunyaev Shamil R
Abstract excerpt
Negative selection against deleterious alleles produced by mutation influences within-population variation as the most pervasive form of natural selection. However, it is not known whether deleterious alleles affect fitness independently, so that cumulative fitness loss depends exponentially on the number of deleterious alleles, or synergistically, so that each additional deleterious allele results in a larger...
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