Article

A STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis

2024-09-19

Abstract excerpt

<h4>ABSTRACT</h4> The cohesin complex is a critical regulator of gene expression. STAG2 is the most frequently mutated cohesin subunit across several cancer types and is a key tumor suppressor in lung cancer. Here, we coupled somatic CRISPR-Cas9 genome editing and tumor barcoding with an autochthonous oncogenic KRAS-driven lung cancer model and show that STAG2 is uniquely tumor suppressive among all core and aux...

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Literature Corpus work: 000f4af5-a00a-5f0c-a147-d8c85f9c94b5
DOI: 10.1101/2024.09.14.613043

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