Article

SATB2 and circ3915 RNA chromatin dysregulation drive <i>KRAS</i> -like oncogenic transformation

2024-10-04

Abstract excerpt

<h4>ABSTRACT</h4> Even though epigenetic factors contribute to oncogenesis, most human cancer models still assume that disease originates from driver DNA mutations. Thus, it is still unclear if non-genetic mechanisms are sufficient to trigger malignant transformation. Special AT-rich binding protein 2 (SATB2) is a chromatin organizer that brings distal DNA elements into close proximity, thus remodeling chromatin...

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Literature Corpus work: 08eb1704-ba3b-517a-8419-d99eda9bb475
DOI: 10.1101/2024.10.04.616681

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