Article

Cohesin constrains histone modification-driven chromatin dynamics

2025-12-16

Abstract excerpt

<h4>ABSTRACT</h4> Gene expressions are regulated by an interplay between epigenetics and spatial genome organization, the deregulation of which has been implicated in the development of cancers, including myeloid neoplasms. However, it is unclear how they coordinately contribute to normal and malignant hematopoiesis. Here, we show that simultaneous dysregulations of histone modifications and chromatin structures...

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Literature Corpus work: 710ba46c-f3e9-5ce9-ab43-0cf82b265c16
DOI: 10.64898/2025.12.13.694149

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