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PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer

2 Aug 2021

Abstract excerpt

Abstract Abnormalities in genetic and epigenetic modifications can lead to drastic changes in gene expression profiles that are associated with various cancer types. Small cell lung cancer (SCLC) is an aggressive and deadly form of lung cancer with limited effective therapies currently available. By utilizing a genome-wide CRISPR-Cas9 dropout screen in SCLC cells, we identified paired box protein 9 (PAX9) as an...

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PMID: 34341073
DOI: 10.1158/0008-5472.can-21-1114

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