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Article

Systematic In Vivo Inactivation of Chromatin-Regulating Enzymes Identifies Setd2 as a Potent Tumor Suppressor in Lung Adenocarcinoma.

Cancer research - 1 Apr 2017

Walter David M, Venancio Olivia S, Buza Elizabeth L, Tobias John W, Deshpande Charuhas, Gudiel A Andrea, Kim-Kiselak Caroline, Cicchini Michelle, Yates Travis J, Feldser David M

Abstract excerpt

Chromatin-modifying genes are frequently mutated in human lung adenocarcinoma, but the functional impact of these mutations on disease initiation and progression is not well understood. Using a CRISPR-based approach, we systematically inactivated three of the most commonly mutated chromatin regulatory genes in two KrasG12D-driven mouse models of lung adenocarcinoma to characterize the impact of their loss....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28202515
DOI: 10.1158/0008-5472.CAN-16-2159
PMCID: PMC5380596

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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