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Article

BRCA1 gene mutation and loss of heterozygosity on chromosome 17q21 in primary prostate cancer.

International journal of cancer - 19 Feb 1999

Uchida T, Wang C, Sato T, Gao J, Takashima R, Irie A, Ohori M, Koshiba K

Abstract excerpt

The tumor suppressor gene BRCA1 on chromosome 17q21 has been characterized and shown to be mutated in patients with familial breast and ovarian cancer. Several studies examined the relatives of women with breast cancer and noted an association with ovarian and prostate cancer. This study investigated 24 human prostate cancer specimens for BRCA1 gene mutations and loss of heterozygosity (LOH) on chromosome 17q21...

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Share to Loss of Heterozygosity
Share to BRCA1 Protein
Share to Chromosomes, Human, Pair 17

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Neoplasm Staging

Share to Polymerase Chain Reaction

Share to Polymorphism, Single-Stranded Conformational

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Source

Identifiers

PMID: 9988226
DOI: 10.1002/(sici)1097-0215(19990219)84:1<19::aid-ijc4>3.0.co;2-s

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BRCA1 gene mutation and loss of heterozygosity on chromosome 17q21 in primary prostate cancer.PMID 9988226Read ↗

Loss of heterozygosity of the BRCA1 and other loci on chromosome 17q in human prostate cancer.Semantic proximity Read ↗

Loss of heterozygosity on chromosome 17q11-21 in cancers of women who have both breast and ovarian cancer.Semantic proximity Read ↗

Truncating BRCA1 mutations are uncommon in a cohort of hereditary prostate cancer families with evidence of linkage to 17q markers.Semantic proximity Read ↗

Loss of chromosome 17 loci in prostate cancer detected by polymerase chain reaction quantitation of allelic markers.Semantic proximity Read ↗

Detection of allelic losses on 17q12-q21 chromosomal region in benign lesions and malignant tumors occurring in a familial context.Semantic proximity Read ↗

CGH analysis of familial non-BRCA1/BRCA2 breast tumors and mutation screening of a candidate locus on chromosome 17q11.2-12.Semantic proximity Read ↗

Evidence for involvement of BRCA1 in sporadic breast carcinomas.Semantic proximity Read ↗

An uncertain role for p53 gene alterations in human prostate cancers.Semantic proximity Read ↗

BRCA1 and prostate cancer.Semantic proximity Read ↗

Genetic and molecular heterogeneity of breast cancer cells.Semantic proximity Read ↗

Familial male breast cancer is not linked to the BRCA1 locus on chromosome 17q.Semantic proximity Read ↗

BRCA1 mutations in primary breast and ovarian carcinomas.Semantic proximity Read ↗

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