Article
CGH analysis of familial non-BRCA1/BRCA2 breast tumors and mutation screening of a candidate locus on chromosome 17q11.2-12.
International journal of molecular medicine - 1 Jul 2005
Maguire Paula, Holmberg Kerstin, Kost-Alimova Maria, Imreh Stefan, Skoog Lambert, Lindblom Annika
Abstract excerpt
Mutations in the known predisposing breast cancer genes BRCA1 and BRCA2 account for only a small proportion (<10%) of breast cancer families in the Stockholm region of Sweden. This study aims to identify novel predisposing genes in non-BRCA1/BRCA2 breast cancer families. We have employed comparative genomic hybridization (CGH) and loss of heterozygosity (LOH) data in combination with data from a recently carried...
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