Article
BRCA1 and prostate cancer.
Cancer investigation - 1 Jan 2001
Rosen E M, Fan S, Goldberg I D
Abstract excerpt
The breast cancer susceptibility gene BRCA1 on chromosome 17q21 encodes an 1863 amino acid protein that is important for normal embryonic development. Germline mutations of this gene are linked to a significantly increased lifetime risk for breast and/or ovarian cancer, and recent studies suggest that the same may be true for prostate cancer. Several activities that may contribute to the tumor suppressor function...
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