Article
Genetic and molecular heterogeneity of breast cancer cells.
Clinica chimica acta; international journal of clinical chemistry - 30 Jul 1993
Callahan R, Cropp C, Merlo G R, Diella F, Venesio T, Lidereau R, Cappa A P, Lisicia D S
Abstract excerpt
We have undertaken a systematic study of primary human breast tumor DNAs to identify and characterize frequently occurring somatic mutations. Loss of heterozygosity (LOH) was found on chromosomes 1p (37%), 1q (20%), 3p (30%), 7 (41%), 13q (30%), 17p (49%), 17q (29%) and 18q (34%) in our tumor DNA...
Topics
- Animals
- Breast Neoplasms
- DNA, Neoplasm
- Genetic Variation
- Humans
- Mice
- Mice, Transgenic
- Mutation