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Article

Detection of allelic losses on 17q12-q21 chromosomal region in benign lesions and malignant tumors occurring in a familial context.

Oncogene - 1 Feb 1994

Lalle P, De Latour M, Rio P, Bignon Y J

Abstract excerpt

A predisposing gene (BRCA-1) for breast and ovarian cancer has been located on chromosomal region 17q12-21. According to Knudson's hypothesis if this gene is a tumor suppressor gene, allelic losses would be found in tumors occurring in families with cancer aggregations. We studied 25 samples of both benign lesions and malignant tumors, from breast cancer site-specific families and other familial cancer...

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PMID: 8290255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Detection of allelic losses on 17q12-q21 chromosomal region in benign lesions and malignant tumors occurring in a familial context.PMID 8290255Read ↗

Four separate regions on chromosome 17 show loss of heterozygosity in familial breast carcinomas.Semantic proximity Read ↗

Detailed deletion analysis of sporadic breast tumors defines an interstitial region of allelic loss on 17q25.Semantic proximity Read ↗

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CGH analysis of familial non-BRCA1/BRCA2 breast tumors and mutation screening of a candidate locus on chromosome 17q11.2-12.Semantic proximity Read ↗

Allele losses in the region 17q12-21 in familial breast and ovarian cancer involve the wild-type chromosome.Semantic proximity Read ↗

A deletion unit on chromosome 17q in epithelial ovarian tumors distal to the familial breast/ovarian cancer locus.Semantic proximity Read ↗

High frequency of allelic imbalance at the BRCA1 region on chromosome 17q in both familial and sporadic ductal breast carcinomas.Semantic proximity Read ↗

A 400 kb novel deletion unit centromeric to the BRCA1 gene in sporadic epithelial ovarian cancer.Semantic proximity Read ↗

Evidence for involvement of BRCA1 in sporadic breast carcinomas.Semantic proximity Read ↗

Loss of heterozygosity on chromosome 17q11-21 in cancers of women who have both breast and ovarian cancer.Semantic proximity Read ↗

22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors.Semantic proximity Read ↗

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