Detection of allelic losses on 17q12-q21 chromosomal region in benign lesions and malignant tumors occurring in a familial context.

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Article

Detection of allelic losses on 17q12-q21 chromosomal region in benign lesions and malignant tumors occurring in a familial context.

Oncogene - 1 Feb 1994

Lalle P, De Latour M, Rio P, Bignon Y J

Abstract excerpt

A predisposing gene (BRCA-1) for breast and ovarian cancer has been located on chromosomal region 17q12-21. According to Knudson's hypothesis if this gene is a tumor suppressor gene, allelic losses would be found in tumors occurring in families with cancer aggregations. We studied 25 samples of b...

Topics

Alleles
Base Sequence
Breast Neoplasms
Chromosomes, Human, Pair 17
DNA, Neoplasm
Family Health
Female
Fibroadenoma
Genes, Tumor Suppressor
Heterozygote
Humans
Hyperplasia
Male
Molecular Sequence Data
Ovarian Neoplasms
Polymerase Chain Reaction
Prostatic Neoplasms

Source

Open in PubMed

Identifiers

PMID: 8290255

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8290255-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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