Article
Loss of heterozygosity of the BRCA1 and other loci on chromosome 17q in human prostate cancer.
Cancer research - 1 Mar 1995
Gao X, Zacharek A, Salkowski A, Grignon D J, Sakr W, Porter A T, Honn K V
Abstract excerpt
A putative tumor suppressor gene, the BRCA1 gene, on chromosome 17q21 has recently been identified and shown to be mutated in breast and ovarian cancers. We have undertaken the present study to explore the possible involvement of the BRCA1 and/or other potential genes on chromosome 17q in prostate cancer. Twenty-three patients were screened by PCR for loss of heterozygosity at five microsatellite loci spanning...
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