Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Familial male breast cancer is not linked to the BRCA1 locus on chromosome 17q.

Nature genetics - 1 May 1994

Stratton M R, Ford D, Neuhasen S, Seal S, Wooster R, Friedman L S, King M C, Egilsson V, Devilee P, McManus R

Abstract excerpt

Breast cancer in men is about a hundredfold less common than in women and this has hindered research into its genetic basis. We have examined 22 families with at least one case of male breast cancer for linkage to the hereditary breast and ovarian cancer locus, BRCA1, on chromosome 17q. We found strong evidence against linkage to BRCA1 (lod score-16.63) and the best estimate of the proportion of linked families...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Chromosomes, Human, Pair 17

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Markers

Share to Genetic Predisposition to Disease

Share to Lod Score

Share to Pedigree

Share to Risk Factors

Share to Sex Factors

Source

Identifiers

PMID: 8075631
DOI: 10.1038/ng0594-103

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Familial male breast cancer is not linked to the BRCA1 locus on chromosome 17q.PMID 8075631Read ↗

An evaluation of genetic heterogeneity in 145 breast-ovarian cancer families. Breast Cancer Linkage Consortium.Semantic proximity Read ↗

Breast cancer incidence, penetrance and survival in probable carriers of BRCA1 gene mutation in families linked to BRCA1 on chromosome 17q12-21.Semantic proximity Read ↗

Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium.Semantic proximity Read ↗

Familial breast cancer. Approaching the isolation of a susceptibility gene.Semantic proximity Read ↗

Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21Semantic proximity Read ↗

Linkage of familial breast cancer to chromosome 17q21 may not be restricted to early-onset disease.Semantic proximity Read ↗

Linkage to BRCA2 region in hereditary male breast cancer.Semantic proximity Read ↗

Genome-wide scan for prostate cancer susceptibility genes using families from the University of Michigan prostate cancer genetics project finds evidence for linkage on chromosome 17 near BRCA1.Semantic proximity Read ↗

Risks of cancer in BRCA1-mutation carriers. Breast Cancer Linkage Consortium.Semantic proximity Read ↗

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.Semantic proximity Read ↗

Genetic analysis of eight breast-ovarian cancer families with suspected BRCA1 mutations.Semantic proximity Read ↗

Modifying effect of reproductive risk factors on the age at onset of breast cancer for German BRCA1 mutation carriers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.