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Article

Loss of chromosome 17 loci in prostate cancer detected by polymerase chain reaction quantitation of allelic markers.

Genes, chromosomes & cancer - 1 Aug 1995

Brothman A R, Steele M R, Williams B J, Jones E, Odelberg S, Albertsen H M, Jorde L B, Rohr L R, Stephenson R A

Abstract excerpt

Using a polymerase chain reaction/microsatellite marker system, we demonstrated that 6 of 22 (27%) clinical stage B (early) primary prostate tumors showed loss of heterozygosity at one or more of five loci on chromosome 17. The sensitivity of this study was increased by use of a PhosphorImager and statistical analysis of replicate tumor-normal DNA pairs. Two patients showed tumor-specific interstitial loss at a...

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Identifiers

PMID: 7547636
DOI: 10.1002/gcc.2870130408

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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