Article
Loss of chromosome 17 loci in prostate cancer detected by polymerase chain reaction quantitation of allelic markers.
Genes, chromosomes & cancer - 1 Aug 1995
Brothman A R, Steele M R, Williams B J, Jones E, Odelberg S, Albertsen H M, Jorde L B, Rohr L R, Stephenson R A
Abstract excerpt
Using a polymerase chain reaction/microsatellite marker system, we demonstrated that 6 of 22 (27%) clinical stage B (early) primary prostate tumors showed loss of heterozygosity at one or more of five loci on chromosome 17. The sensitivity of this study was increased by use of a PhosphorImager an...
Topics
- Alleles
- Case-Control Studies
- Chromosome Deletion
- Chromosomes, Human, Pair 17
- Genetic Markers
- Humans
- Male
- Microsatellite Repeats
- Polymerase Chain Reaction
- Prostatic Neoplasms