Article
BRCA1 mutations in primary breast and ovarian carcinomas.
Science (New York, N.Y.) - 7 Oct 1994
Futreal P A, Liu Q, Shattuck-Eidens D, Cochran C, Harshman K, Tavtigian S, Bennett L M, Haugen-Strano A, Swensen J, Miki Y
Abstract excerpt
Loss of heterozygosity data from familial tumors suggest that BRCA1, a gene that confers susceptibility to ovarian and early-onset breast cancer, encodes a tumor suppressor. The BRCA1 region is also subject to allelic loss in sporadic breast and ovarian cancers, an indication that BRCA1 mutations...
Topics
- Adult
- Age of Onset
- Alleles
- BRCA1 Protein
- Base Sequence
- Breast Neoplasms
- Chromosomes, Human, Pair 17
- Female
- Genes, Tumor Suppressor
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Heterozygote
- Humans
- Middle Aged
- Molecular Sequence Data
- Neoplasm Proteins
- Ovarian Neoplasms
- Transcription Factors