Article
Loss of heterozygosity on chromosome 17q11-21 in cancers of women who have both breast and ovarian cancer.
American journal of obstetrics and gynecology - 1 Mar 1995
Schildkraut J M, Collins N K, Dent G A, Tucker J A, Barrett J C, Berchuck A, Boyd J
Abstract excerpt
OBJECTIVE: Our purpose was to determine the frequency of allele loss in the region of the BRCA1 gene in cancers of women who have both breast and ovarian cancer. STUDY DESIGN: Four polymorphic microsatellite markers on chromosome 17q11-21 were examined by the polymerase chain reaction in deoxyribonucleic acid from paraffin blocks of normal tissues, breast cancers, and ovarian cancers in 24 women who had primary...
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