CD4-mediated inhibiton of IL-2 production in activated T cells.

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Article

CD4-mediated inhibiton of IL-2 production in activated T cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 1999

Bonnard M, Haughn L, Julius M

Abstract excerpt

The role of CD4 in T cell activation has been attributed to its capacity to increase the avidity of interaction with APC and to shuttle associated Lck to the TCR/CD3 activation complex. The results presented in this study demonstrate that ligation of CD4 inhibits ongoing responses of preactivated...

Topics

Animals
Antibodies, Monoclonal
Antigen-Presenting Cells
Antigens
CD4 Antigens
Clone Cells
Down-Regulation
Interleukin-2
Lymphocyte Activation
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mutation
Ovalbumin
RNA, Messenger
T-Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 9973377

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9973377-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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