Article
Alterations in CD4 dependence accompany T cell development and differentiation.
International immunology - 1 Jul 1996
Yelon D, Spain L M, Lim K, Berg L J
Abstract excerpt
Several studies have indicated that the necessity for co-receptor engagement during T cell activation depends on the avidity of the TCR-MHC interaction under investigation. Using thymocytes, naive T cells and a long-term T cell line isolated from 2B4 TCR transgenic mice, we have examined the role...
Topics
- Animals
- CD4 Antigens
- Cell Differentiation
- Cell Line
- Histocompatibility Antigens Class II
- Immunoglobulin Fab Fragments
- Mice
- Mice, Transgenic
- Mutation
- Protein Binding
- Receptors, Antigen, T-Cell
- Signal Transduction
- T-Lymphocytes