Article
Alterations in CD4 dependence accompany T cell development and differentiation.
International immunology - 1 Jul 1996
Yelon D, Spain L M, Lim K, Berg L J
Abstract excerpt
Several studies have indicated that the necessity for co-receptor engagement during T cell activation depends on the avidity of the TCR-MHC interaction under investigation. Using thymocytes, naive T cells and a long-term T cell line isolated from 2B4 TCR transgenic mice, we have examined the role of the CD4 co-receptor on cells expressing the identical TCR at multiple stages of T cell maturation. When anti-CD4...
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