The cytoplasmic domain of CD4 is required for stable association with the lymphocyte-specific tyrosine protein kinase p56lck.

doi:10.1002/eji.1830200628

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Article

The cytoplasmic domain of CD4 is required for stable association with the lymphocyte-specific tyrosine protein kinase p56lck.

European journal of immunology - 1 Jun 1990

Veillette A, Sleckman B P, Ratnofsky S, Bolen J B, Burakoff S J

Abstract excerpt

The CD4 T cell surface molecule binds MHC class II determinants expressed on antigen-presenting cells. CD4 is thought to enhance T cell activation by serving as an adhesion molecule as well as possibly by transducing an independent intracellular signal during the process of antigen stimulation. T...

Topics

Amino Acid Sequence
Animals
CD4 Antigens
Cell Line
Cytoplasm
Humans
Hybridomas
Mice
Molecular Sequence Data
Mutation
Protein-Tyrosine Kinases
Structure-Activity Relationship
T-Lymphocytes

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