Article
Differential T cell signaling induced by antagonist peptide-MHC complexes and the associated phenotypic responses.
Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 1997
La Face D M, Couture C, Anderson K, Shih G, Alexander J, Sette A, Mustelin T, Altman A, Grey H M
Abstract excerpt
Certain changes in TCR contact residues have been shown to have profound effects on the capacity of a peptide Ag to stimulate a T cell response. Although some of these changes apparently lead to a complete loss of the ability to interact with the TCR, others result in partial agonist activity (e....
Topics
- Amino Acid Sequence
- Animals
- Down-Regulation
- Enzyme Activation
- Histocompatibility Antigens Class II
- Mice
- Molecular Sequence Data
- Peptides
- Phenotype
- Phosphorylation
- Phosphotyrosine
- Protein-Tyrosine Kinases
- Receptors, Antigen, T-Cell
- Signal Transduction