Article
An anti-CD2 monoclonal antibody that both inhibits and stimulates T cell activation recognizes a subregion of CD2 distinct from known ligand-binding sites.
Cellular immunology - 1 Sept 1993
Kozarsky K F, Tsai C, Bott C M, Allada G, Li L L, Fox D A
Abstract excerpt
The T lymphocyte glycoprotein CD2 appears to have an important role in human T cell development and activation. A novel anti-CD2 monoclonal antibody, designed UMCD2, was shown to block E rosetting, and therefore was defined as recognizing the Tll1 ligand-binding epitope. Binding of UMCD2 to T cells and thymocytes was blocked by several, but not all, anti-Tll1 antibodies, suggesting that the Tll1 epitope consists...
Topics
- Amino Acid Sequence
- Antibodies, Monoclonal
- Antigens, Differentiation, T-Lymphocyte
- Binding Sites
- CD2 Antigens
- Calcium
- Cells, Cultured
- Humans
- Lymphocyte Activation
- Molecular Sequence Data